Studies Regarding antifungal resistance of Candida species

Abstract

Immune imbalance, as a result of different pathologies, of certain physiological states or as a result of certain medicine administration, favorizes mycotic infection development, especially those determined by Candida spp. The purpose of this study was to test the sensitivity or resistance of Candida species from several pathologic products, to some antifungal medicines. The study included 180 patients hospitalized at Slatina Municipal Hospital, during March 2017-February 2018. Out of the patients, 69. 44% were female and 30. 56% were male. The following pathological products were used: vaginal secretion, wound secretion, spit and urine. The patients were distributed in 2 groups, based on the method used for testing the sensibility of the Candida species. Samples derived from the first group were processed with the Vitek device, testing the species’ resistance to the following drugs: fluconazole, voriconazole, caspofungin, amphotericin B, flucytosine. For the second group, the fungigrama was performed manually, testing the species resistance to fluconazole, amphotericin B, nystatin, clotrimazole, intraconazole, ketoconazole, miconazole. For the two testing methods, the first group developed a sensitivity of 86.87% against fluconazole and 89.90% against amphotericin B, while for the second group, the sensitivity varied as follows: 29.63% against fluconazole and 74.07% against amphotericin B. The study results proved an important variability of Candida strains from different pathologic products against different antifungal medicines.

 

Table of Contents:

1. Introduction

2. Methods

3. Results

4. Conclusions

 

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The Authors:

ILIE Marina-Ionela [1]

RĂDUȚ Teodora [1]

ARSENE Andreea Letiția [1]

[1] “Carol Davila”, Bucharest University of Medicine and Pharmacy, Faculty of Pharmacy, (ROMANIA).

 

Contributo selezionato da Filodiritto tra quelli pubblicati nei Proceedings “17th Romanian National Congress oh Pharmacy – 21st Century Pharmacy – Between Intelligent Specialization and Social Responsibility - 2018”

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Contribution selected by Filodiritto among those published in the Proceedings “17th Romanian National Congress oh Pharmacy – 21st Century Pharmacy – Between Intelligent Specialization and Social Responsibility - 2018”

To buy the Proceedings click here.